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Full List of all known drugs -which are  to be avioded in

Mast cell conditions .



Radiographic contrast - esp CT contrast and when used for angiograms


Opites -esp morphine, codines , fentnyl , pethedine


Dextran /Dextrin -In plasma expander fluids /colloids  ,eyedrops and foods


Alochol - ethanol as preservative


Mycin antibiotics - antibiotic drug name which ends in mycin


Beta blockers - bring on reactions and interact with epinepeherine ( by working on alpha receptors- deepen ing hypotension (low blood pressure ) and bradycardia (Low pulse ) . The drug name of beta blockers- end in OL - sotalol , bisoprolol


Cause increase in serotonin and it can already be high in many .So ssri's /ssni can cause serotonin syndrome


Heparin -activates mast cells .also injection with high - Chondroitin Sulfate and or alcohol


Muscle relaxants - Pancuronium, alcuronium, D-tubocurarine


Narcotics - Thiopental


Analgetics - Morphine, pethidine, nonsteroidal anti-inflammatory drugs (NSAIDs), acetylsalicylic acid (aspirin), metamizole


Local anesthetics - Prilocaine


Antihypotonics - Dobutamine


Antihypertensive drugs - Verapamil, alprenolol, dihydralazine


Antiarrhythmics - Propafenone


Diuretics - Amiloride (water tablets )


Drugs influencing gut motility - Metoclopramide (antisickness)


Antibiotics - Cefuroxime, cefotiam, -Ceftriaxones -(10% cross over with penicillin so not given if patient penicillin anaphylaxis )


isoniazid, (Laniazid, Nydrazid), TB treatment



Antiprotozoal agent effective in Trypanosomiasis, Leishmaniasis, and some fungal Infections; used in treatment of Pneumocystis Pneumonia in HIV-infected Patients. It may cause Diabetes Mellitus, Central Nervous System damage, and other toxic effects.


clavulanic acid, - In Augmentin - co amociclav




Polymixin and assoc - PolysporinNeosporinPolymyxin BPolymyxin E

found often in eye and ear drops


Amphoteractin -(Fungilin, Fungizone, Abelcet, AmBisome, Fungisome, Amphocil, Amphotec


Mucolytics - Acetylcysteine, ambroxol


Broncholytics - Aminophylline ( emergency asthma treatment) daily version theophylline


H2-receptor antagonists


(interacts with statins and other drugs )


Cytostatics - Cyclophosphamide


Antidepressants - Amitriptyline

Epipen interactions


Beta blockers - cause alpha recpetor responses - low pulse ,lower BP , airway spasm .




Tricyclic antidepressants - amitryptylline ,Nortryptylline

Caution with other ingredients  - commonly including -

corn flour /maize starch

sweetners - malt o dextrin , a sulpahmine K ,

sodium leureth sulphate






sulphite preservatives

e200-228 and e160 a-d




each person has different issues

Affects some but not others -


Sulphur based medictions inc antibiotics - best place to check if amedicine is asulphur base - wikipedia -it has the chemical name on the right hand side of the page .

Known drugs -

Diamox - used in EDS ,is sulphur based and has caused anaphylaxis

Frousamide - diuretic


Quinoline antibiotics - levoquin , ciprofloxicillin . Also strong so i advise having probiotic drinks alongside these .




BNF online