Phenergan

Phenergan -

 

Is a drowsy antihistamine and works on the vomiting centre in the brain .Useful in individuals with vertigo symptoms and nausea not improved by h2 blockers

 

Warning!

 

This medicine should not be used for longer than seven days without seeking medical advice from your doctor.

 

This medicine may cause drowsiness that can last up to 12 hours. If affected you should not perform potentially hazardous tasks such as driving or operating machinery. You should avoid drinking alcohol because it is likely to make any drowsiness worse.

 

This medicine may make your skin more sensitive to sunlight than it usually is, so you should avoid exposing your skin to direct sunlight or sunlamps until you know how your skin reacts. If you can't avoid strong sunlight you should use a sunscreen lotion or make sure your skin is protected with clothing.

 

This medicine may interfere with some pregnancy tests, causing false negative or false positive results.

 

Short shelflife - Phenergan elixir should not be used if the bottle has been open for more than a month. You may find it helpful to write the date you open the bottle on the label. Any syrup remaining in the bottle after it has been open for a month should be carefully disposed of, preferably by returning to your pharmacy.

 

Use with caution in

 

Elderly people.

 

Decreased kidney function.

 

Decreased liver function.

 

Asthma.

 

Bronchitis.

 

A condition called bronchiectasis in which there is persistent and progressive widening of the airways due to lung infections or lung disease, such as cystic fibrosis.

 

Severe coronary artery disease (heart disease).

 

Closed angle glaucoma.

 

Epilepsy.

 

Blockage of the opening from the stomach into the intestines (pyloro-duodenal obstruction).

 

Blockage of the drainage of urine out of the bladder (bladder neck obstruction), for example due to an enlarged prostate gland.

 

Absoslutely contraindicated in - Must NOT be taken

 

Children under two years of age.

 

Reduced awareness, slow reactions or extreme drowsiness due to medicines or illness that reduce activity in the central nervous system (CNS depression).

 

Comatose states.

 

CAUTION DO NOT USE IN - People who have taken a type of medicine called a monoamine oxidase inhibitor (MAOI) in the past 14 days.-Type of antidepressnat

 

This medicine should be avoided in children and adolescents with signs and symptoms suggestive of Reye's Syndrome.

 

Phenergan tablets contain lactose and should not be taken by people with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption.

 

Phenergan elixir contains glucose syrup and is not suitable for people with diabetes or rare hereditary problems of fructose intolerance.

 

Apply your if you react stop using rules with all medicions

 

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

 

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

 

 

 

 

 

Is prescription only in many countries .This is due to its issues see cautions . If it is availble OTC in your country ,please read cautions .It must NOT be overdosed . See legal section .

Has its use at normal doses in patients who can have it .

Legal - http://en.wikipedia.org/wiki/Wyeth_v._Levine

 

The drug company were sued when an IV-into avein througha plastic cannula -caused gangrene . So this product must not be given intravenously . Into a muscle is safe . As a result benadryl has been replaced as drug of choice in Anapahylaxis .

 

Overdose - http://www.nlm.nih.gov/medlineplus/ency/article/002527.htm

In mast cell we see our doctors prescribing over the limits on the bottle .This is done with medicines in which this has been proven to be safe -Phergan is NOT one of those drugs with which it is safe to do this .

Legal and overdose

UK Guidelines - Jan 2013 - if more than 6 months old

check BNF via link

NHS choices

http://www.nhs.uk/medicine-guides/pages/MedicineOverview.aspx?condition=Allergic%20conditions&medicine=Promethazine%20Hydrochloride&preparation=Promethazine%20hydrochloride%2010mg%20tablets

 

BNF - British National Formulary

-which is the Doctors prescribing bible

-and is updated every 6 months

 

http://www.medicinescomplete.com/mc/bnf/current/PHP1896-antihistamines.htm

 

http://www.medicinescomplete.com/mc/bnf/current/PHP1950-promethazine-hydrochloride.htm

Drowsiness

Mast cell patients - This is specific advice

Find that they can not be drowsy

Those that do find it improves with regualr dosing over 2 weeks

Heart

Antihistamines -can cuase fast heart rate - so if you have any known heart problems or EDS 3 then this side effect needs to be watched for

 

Phenergan is new to mast cell patients as its coming back into use .

 

Histamine -which this drug is stopping acting causes high pulse and due to fluid loss -high pulse for a period of time . So the balance with antihistamines is they imporove these effects so - heart rate should improve .

 

In those without known heart problems the ebnfit could outweigh the risks

 

BUT

 

becuase this drug has certain exceptions - people who MUST NOT have it - It is not availble OTC (over the counter ) in most countries .

 

 

Disclaimer - The information on this site is information but not medical advice if you have any concerns please discuss this with your doctor or pharmacist .If you feel your doctor or pharamacist isnt serving your needs please contact me for direct advice in individual cases . Use the form below

To add your expeiences with specific drugs please click anywere on this section

( this is the link )

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The aim of this is to enable specific discussion of side effects and reduce the amount of scary misinformation online about mast cell drugs specifically .