Here I discuss the chemical processes which mast cell chemicals activate.
Histamine works on the histamine 1 receptor in the adrenal medellla .
The arenal glands are at the top of the kidneys .the centre -medulla -excreete- epipeneherine and nor epinpeherine .
These are known as cateclamines and have varying effects around the body .
The adrenals are protected by the rib cage.
They have recpetors for histamine .there are 4 receptors in total-on adrneals we find H1 and h3
The histamine 1 receptors work in the medulla,
producing epinepherine and norepinepherine.
So medictions blocking the histamine 1 receptor prevent histamine cuasing relase of epinpeherine and norepinpeherine .
Epinpeherine - increases biological functions -
Increases blood pressure
Increases muscle spasm -causing contraction of muscles inc heart , blood vessels , lung linings ,
Increases strength of heart contractions .
Nor epinpeherine - Lowers -
Lowers blood pressure
Lowers muscle tone - allowing blood vessels to be relaxed
The Sympathetic nervous system and parasymapthetic - form part of the autonomic nervous system .
So the actions of epinpeherine - adrenaline (the same )
Nor epinpeherine - Nor epinpeherine
Have effects on the automatic control of our core body functions -
Blood pressure - Explained -
Blood pressure is made up of 2 numbers .
The first the systolic and the second is the diastolic
This is the pressure that the heart is pumping out blood from the left ventrcle - at the beginning of the heart beat
The diastolic is the pressure the blood is being pumped out at the end of the heart beat .
Why is this important -This is important becuase below a certain level the blood isnt pumped hard enough to get to the organs / muscles/ bones - were its oxygen is needed to produce energy for cell function and carbon dioxide needs to be removed .
If its too high -over time it causes dmaage to blood vessels , the heart gets damaged -gets big and flabby so cnat pump properly .The damage in the blood vessels leads to a rough surface for cholesterol to collect causing narrowing of the vessels , bulges in vessels -called anuersyms .
So what is normal - or safe blood pressure ?
The top figure systolic must be over 90 for organs to get enough blood to meet its needs - to allow it to function .
The brain can not make energy without oxygen - others can for a short period - so systolic below 90 is dnagerous for all organs .
High -Top figure over 150 is seen as high and will cuase damage over time .
over 170 there is high rick of a vessel breaking splilling blood and